Current genomic profiling technologies can generate a vast amount of data and carry a large price tag. Deciding which tool is the best one for the job can be difficult. This talk will discuss different technologies and applications for each as well as present case studies utilizing these technologies from both our research-based core facility and the clinical diagnostic laboratories at the Baylor College of Medicine. Current Array Comparative Genomic Hybridization (aCGH) or Chromosomal Microarray Analysis (CMA) performed at Baylor College of Medicine (BCM) utilizes the latest microarray technology to detect unbalanced chromosome abnormalities associated with over 210 clinical disorders with exon by exon coverage of over 1,700 genes. We have performed approximately 42,000 postnatal CMA tests. Additionally, we have CMA results on more than 1,000 clinical prenatal samples. We will also report our CMA experience with cancer genetic testing. In 2010, BCM opened the Cancer Genetics Laboratory (CGL). The CGL is a combined effort of the Department of Molecular & Human Genetics, the Department of Medicine Division of Hematology/Oncology, and the Texas Children’s Hospital Pathology Laboratory. The CGL is able to provide gene sequencing testing (using both Sanger-based sequencing and next generation sequencing technologies), deletion/duplication testing, chromosome analysis, FISH testing, and chromosomal microarray analysis (CMA) for both the pediatric and adult cancers. This Life Sciences Advanced Technology Seminar is jointly sponsored by the Cornell University Life Sciences Core Laboratories Center and the Department of Physiology & Biophysics of the Weill Cornell Medical College.