The Weill Institute is pleased to welcome Dawen Cai (Professor of Cell and Developmental Biology, Michigan Neuroscience Institute, U. Michigan) to the Molecular Cell Bio Group for a seminar on mapping neural circuits: "Super-resolution profiling of neuron morphology, synapse connectivity, and molecular identity." Join us on Thursday, April 3rd, in Weill Hall 226 at 4pm. Light refreshments will be offered.

Neural circuits, composed of intercellular connected neurons with distinct properties lay the

physical foundation of any brain function. Identifying subtypes and connections of individual

neurons in a circuit is the key to understanding how information is processed and propagated in

the brain. In order to obtain a detailed wiring diagram between neurons, we developed a series of

sample preparation, multiplex labeling, microscopy, and image processing technologies to allow

neuronal identity and connectivity features to be directly measured in a densely labeled mouse

brain. Compatible with standard surgical, imaging, and computational instrumentations, our

comprehensive circuit mapping toolset will also allow high-resolution neural circuit mapping or

general molecular spatial profiling in a broad community.

Molecular Cell Bio Group, hosted by the Weill Institute for Cell and Molecular Biology, is a monthly interdisciplinary meeting to provide opportunities for labs across Cornell's Ithaca campus to network and share research and knowledge related broadly to cell and molecular biology. We hope these meetings encourage future collaborations and the sharing of materials and ideas.