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X-WR-CALNAME: MAE Colloquium: Amir Vahabikashi\, PhD
X-WR-TIMEZONE:Eastern Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20260716T233955Z
UID:tag:localist.com\,2008:EventInstance_42581152845098
DTSTART:20230321T200000Z
DTEND:20230321T210000Z
DESCRIPTION:Title: Unveiling the Potential of Multiscale Mechanobiology: Fr
 om Discovery to Therapeutics and Regeneration\n\nAbstract: Cells and tissu
 es in living organisms are continually exposed to mechanical stimuli. Ther
 e is growing evidence that the interplay between these stimuli and cellula
 r processes\, referred to as mechanobiology\, plays a significant role in 
 several physiological phenomena including cell function\, migration\, tiss
 ue repair\, and regeneration. I will demonstrate that the altered mechanob
 iology of Schlemm's Canal endothelium and its underlying substrate is a ke
 y factor in the pathology of primary open-angle glaucoma\, and that this d
 iscovery can be used to develop new therapeutics for this disease. I will 
 also show that selective engagements between the cell nucleus and cytoskel
 etal systems can regulate cell stiffness and contractile state in a distin
 ctive manner. These interactions\, which are mediated by the interplay bet
 ween the nucleoskeleton and the linker of nucleoskeleton and cytoskeleton 
 (LINC) complexes\, provide insights into mechanisms for cellular defects o
 bserved in laminopathies and many cancers. Lastly\, I will exhibit the pot
 ential of compliant two and three-dimensional bioelectronic interfaces for
  organoid and tissue-scale mechanobiology studies and their possible appli
 cations in disease investigations and regenerative engineering. My overall
  research program aims to harness the power of soft bioelectronics and mul
 tiscale mechanobiology to understand the mechanisms of human development a
 nd disease and to apply this knowledge to develop new therapeutic and rege
 nerative strategies for various diseases. \n\nBiosketch: Amir Vahabikashi 
 is a postdoctoral research fellow at Northwestern University\, where he ho
 lds joint appointments in the Querrey Simpson Institute for Bioelectronics
  and the Cell and Developmental Biology Department. He earned his B.Sc. 
 and M.Sc. in Mechanical Engineering from K.N.Toosi University of Technol
 ogy in Iran and Villanova University\, respectively. His doctoral studies 
 at Northwestern University's Biomedical Engineering Department\, under Pro
 f. Mark Johnson\, focused on the mechanobiology of outflow tissue in prima
 ry open-angle glaucoma. As a postdoctoral fellow in Prof. Robert Goldman's
  lab\, he studied the role of the cytoskeleton and nucleuskeleton in cellu
 lar and nuclear mechanobiology. Currently\, Dr. Vahabikashi is focused on 
 developing compliant two and three-dimensional multimodal bioelectronic in
 terfaces for organoid and tissue-scale mechanobiology studies\, implantabl
 e technologies\, and regenerative engineering in the lab of Prof. John Rog
 ers. He is a recipient of the Pathway to Independence Award (K99/R00) from
  the National Eye Institute\, the Ruth L. Kirschstein National Research Se
 rvice Award from the National Cancer Institute\, and the Innovation Corps 
 Award from the National Science Foundation. His goal is to use the combina
 tion of soft bioelectronics and multiscale mechanobiology to understand th
 e mechanisms of human development and disease and develop new therapeutic 
 and regenerative approaches for various illnesses.
GEO:42.443844;-76.483292
LOCATION:Kimball Hall\, B11
SUMMARY: MAE Colloquium: Amir Vahabikashi\, PhD
URL;VALUE=URI:https://events.cornell.edu/event/mae_colloquium_amir_vahabika
 shi_phd
CATEGORIES:Colloquium
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