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Central Campus
Iwijn De Vlaminck, Department of Biomedical Engineering, Cornell University, Ithaca, NY, will present seminar. Host: Professor Dan Ralph.
Seminar Title: What is in your blood? Small fragments of circulating DNA inform about the health of organ transplants
Abstract: A large number of small fragments of cell-free DNA are present in the blood circulation. These molecules are the byproduct of cell death across the body and offer an information-rich window into physiology, with rapidly expanding applications in prenatal testing and cancer diagnosis. In this talk, I will show that omics-enabled, data-driven analyses of cell-free DNA in the blood of organ transplant patients can inform about post-transplant rejection, infection, immune fitness and inflammation. I will show that high-throughput sequencers can be used as digital profilers to study the biophysical properties of cell-free DNA and I will discuss a new molecular biology technique to capture and sequence ultrashort pieces of cell-free DNA isolated from urine or blood. Last, I will discuss our efforts to use machine learning to identify the tissues-of-origin of cell-free DNA, and I will demonstrate applications of these approaches to the diagnosis of kidney transplant complications.
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