Ayshwarya Subramanian, PhD
Assistant Professor, Molecular Biology and Genetics, Cornell University

Decoding Myeloid Cell States in Kidney Transplant Rejection

We generated a single-cell meta-atlas of kidney transplant biopsies to define myeloid cell diversity across antibody-mediated and T cell-mediated rejection, identifying distinct transcriptional programs in tissue-resident and monocyte-derived macrophages associated with each rejection phenotype. We further found that tissue-resident macrophages comprise both donor- and recipient-derived populations, with recipient-derived resident macrophages exhibiting rejection-associated transcriptomic features that suggest a potential role in shaping local allograft inflammation.

Hilal Bashir, PhD
Postdoctoral Associate in Pediatrics, Weill Cornell Medical College

Defining the Stress–Gut Microbiome Interplay in Anti-Tumor B Cell Response

Chronic stress drives tumor progression by activating a gut microbiota–dependent, phage-mediated circuit that suppresses anti-tumor B cell immunity. We identify a translocating bacterium whose DNA triggers TLR9 in tumor fibroblasts to induce local corticosterone, revealing a targetable pathway to restore B cell responses and improve cancer outcomes.