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VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
X-WR-CALNAME:EDS SEMINAR: Siyang Liu\, Cornell ECE
X-WR-TIMEZONE:Eastern Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20260716T233055Z
UID:tag:localist.com\,2008:EventInstance_4104099
DTSTART:20181116T171500Z
DTEND:20181116T181500Z
DESCRIPTION:Hybrid Adaptve Optics for High-throughput\, Deep\, and Volumetr
 ic Optical Coherence Microscopy\n\n \n\nOptical coherence microscopy (OCM)
  provides non-invasive\, label-free\, cellular-resolution imaging based on
  optical scattering contrast. Its interferometric detection captures the o
 ptical field\, providing opportunities for computational reconstruction. H
 owever\, the depth coverage of OCM is restricted by defocus and photon col
 lection\, and its penetration depth is limited by multiple scattering (MS)
 . Here\, we propose integrating hardware and computational adaptive optics
  in different ways\, to improve the throughput\, penetration depth\, and c
 ontrast of volumetric OCM. This hybrid adaptive optics approach splits the
  image formation process into a combination of hardware and computation co
 mponents. For imaging in sparse environments\, we generated astigmatism us
 ing hardware adaptive optics (HAO) to achieve a more equalized photon dist
 ribution across depth\, and removed the applied aberration (and defocus) v
 ia computational adaptive optics (CAO). \n\n            We applied this hy
 brid adaptive optics method to perform 3D time-lapse imaging of in vitro f
 ibroblast cell dynamics over a 1×1×1mm field-of-view with 2μm isotropic
  spatial resolution and 3 minute temporal resolution. The combination in h
 ardware and computation is not only beneficial for high-throughput volumet
 ric imaging\, but is also capable of suppressing MS/speckle. For imaging i
 n scattering environments\, HAO was used to illuminate the sample volume w
 ith diverse aberrated point spread functions to decorrelate the MS/speckle
  fields\, and CAO was applied to computationally mitigate the resolution p
 enalty of these intentionally induced aberrations. By imaging with this ab
 erration-diverse OCT using 12 volumetric reconstructions\, we achieved a 1
 0 dB enhancement in signal-to-background ratio at a USAF target plane bene
 ath a scattering layer (7.2 scattering mean-free-path)\, and a 3× speckle
  contrast reduction within the scattering layer.
GEO:42.444836;-76.482254
LOCATION:Phillips Hall\, 233
SUMMARY:EDS SEMINAR: Siyang Liu\, Cornell ECE
URL;VALUE=URI:https://events.cornell.edu/event/eds_seminar_siyang_liu_corne
 ll_ece
CATEGORIES:Seminar
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