Cornell University

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Chemistry Seminar- Gyeongjin Park- "Synthesis and Applications of Lewis Acidic Main Group Cations and Oligophosphate Anions"

Tuesday, December 19, 2023 at 4:00pm

Physical Sciences Building, 120
245 East Avenue

Main group chemistry is defined as the chemistry dealing with the main group elements belonging to the s- and p-block elements in the periodic table, known for their abundance and diverse applications of enormous industrial, economic, and environmental importance. This presentation specifically explores the chemistry of main group cations and anions. Firstly, I'll discuss the development of new platforms using cationic main group derivatives for anion transport across phospholipid bilayers. Bearing in mind that the anion transport field has been typically dominated by the use of organic receptors with hydrogen bond donors, I have recently started to investigate cationic main group Lewis acids for anion transport. Secondly, I'll present my research on ambiphilic ligands with a carbene donor and a carbocation, elucidating their construction and their role as scaffolds supporting unique interactions. Lastly, I'll delve into the synthesis and biochemistry application of oligophosphates, particularly a novel reagent for pentaphosphorylation. The presentation will cover the synthesis of nucleoside hexaphosphate and heptaphosphate and their inhibitory effects on RNase A, combining experimental assays, co-crystal structures, and quantum chemical methods. The collaborative efforts in both experimental and computational investigations have the potential to pioneer new avenues in designing inhibitors for RNase A and related enzymes.

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Event Type

Seminar

Departments

Chemistry and Chemical Biology

Contact E-Mail

chemchair@cornell.edu

Contact Name

Lisa Alzo

Contact Phone

607-255-4175

Speaker

Gyeongjin Park

Speaker Affiliation

MIT

Dept. Web Site

https://chemistry.cornell.edu/seminars-and-lectures

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