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X-WR-CALNAME:Chemical Engineering Seminar: Brenton D. Hoffman (Duke Univers
 ity)
X-WR-TIMEZONE:Eastern Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20261011T153414Z
UID:tag:localist.com\,2008:EventInstance_3316910
DTSTART:20180430T130000Z
DTEND:20180430T140000Z
DESCRIPTION:Dr. Brenton Hoffman\nAssistant Professor\nDepartment of Biomedi
 cal Engineering\, Duke University\n\n"Assessing the Effects of Protein Loa
 d on Protein Function"\n\nCells exist in a complex mechanical environment 
 that is a source of applied forces and a means of mechanical support. Cell
 s respond to these mechanical signals through a poorly understood process 
 called mechanotransduction. A clearer understanding of this process will l
 ead to improved methods for manipulating cell behavior in engineered tissu
 es and increased understanding of mechanosensitive disease states\, such a
 s atherosclerosis and cancer. As mechanotransduction is likely due to forc
 e-induced conformation changes in load-bearing proteins\, we develop and u
 se protein-based biosensors that exhibit force-dependent changes in the co
 lor of emitted light. This technology enables dynamic measurements of mech
 anical forces at the molecular level that are innately compatible with con
 cepts and approaches common in molecular biology and biophysics\, uniquely
  enabling mechanistic studies of mechanotransduction. The current challeng
 e is developing approaches that reveal the effects of mechanical loading o
 n protein function in living cells. In this talk\, I will discuss our effo
 rts to develop new assays for probing the relationship between protein loa
 d and the composition of key sub-cellular structures as well as the relati
 onship between protein loading and protein dynamics. I will conclude with 
 a discussion of how these techniques are changing our understanding of the
  mechanisms cells use to detect and respond to mechanical cues.\n\nBio: Dr
 . Brenton Hoffman is an Assistant Professor in the Department of Biomedica
 l Engineering at Duke University where he is the principal investigator of
  the Cell and Molecular Mechanobiology Laboratory. He received a B.S. Degr
 ee in Chemical Engineering from Lehigh University\, a PhD in Chemical and 
 Biomolecular Engineering from the University of Pennsylvania\, and complet
 ed Post-doctoral training in the Cardiovascular Research Center at the Uni
 versity of Virginia. Dr. Hoffman’s current research interests are in the
  areas of cell mechanics\, cell migration\, and mechanotransduction\, with
  a particular focus on the development of new tools and approaches for stu
 dying the effects of mechanical loading on protein function in living cell
 s. His lab has received funding from the National Science Foundation\, the
  National Institutes of Health\, and the American Heart Association. He ha
 s been awarded a Basil O’Connor Starter Scholar Award from the March of 
 Dimes\, a Searle Scholar Award\, and NSF CAREER Award. He has also receive
 d the Klein Family Distinguished Teaching Award\, the highest award in Duk
 e’s Pratt School of Engineering for teaching.
GEO:42.445568;-76.484665
LOCATION:Olin Hall\, 165
SUMMARY:Chemical Engineering Seminar: Brenton D. Hoffman (Duke University)
URL;VALUE=URI:https://events.cornell.edu/event/chemical_engineering_seminar
 _brenton_d_hoffman_duke_university
CATEGORIES:Seminar
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