Shining Light at Early Development and Reproduction

Early mammalian development is a remarkably dynamic process governed by a complex interplay of genetic, molecular, and mechanical factors. Disruptions in these regulatory systems can result in embryonic failure, congenital anomalies, and long-term health complications. To deepen our understanding of these developmental dynamics in vivo, we employed a diverse array of advanced biophotonic technologies. Our work integrates functional optical coherence tomography (OCT), vital fluorescent reporters, optogenetic tools, nonlinear microscopy, and intravital imaging, alongside mouse models of developmental disorders. This multidisciplinary approach has led to several unexpected discoveries that challenge prevailing paradigms in developmental and reproductive biology. By implementing these optical methods in genetic models can bring new insights into the mechanisms of embryogenesis and reproductive health, with promising implications for better management of reproductive disorders and congenital conditions. Moreover, the intricate and fast-evolving nature of early development presents a rich landscape for innovation in optical engineering. The protocols and imaging strategies we have developed offer a powerful platform for laser physicists and engineers to pioneer new technologies, driving forward both biological discovery and technological advancement.
 

Bio: Irina V. Larina is a professor and the Kyle and Josephine Morrow Endowed Chair in the Department of Integrative Physiology at Baylor College of Medicine in Houston. Originally trained in physics at Saratov State University in Russia, she transitioned into biomedical research during her Ph.D. studies at the University of Texas Medical Branch in Galveston. Her research work bridges physics and biology, focusing on the development of advanced optical imaging technologies to study mammalian embryonic development, cardiovascular dynamics, and reproductive biology. Larina is a recipient of numerous honors including the most recent Michael E. DeBakey, M.D. Excellence in Research Award. Larina is a Fellow of the OPTICA Society and a Senior Member of the SPIE Society.