BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
X-WR-CALNAME:Biophysics Colloquium with Megan Thielges
X-WR-TIMEZONE:Eastern Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20260905T213232Z
UID:tag:localist.com\,2008:EventInstance_2944072
DTSTART:20170913T200000Z
DTEND:20170913T210000Z
DESCRIPTION:Megan Thielges\, Indiana University\n\nHost: Roger Loring\n\nCo
 nformations and Dynamics of Protein Molecular Recognition\n\nProtein dynam
 ics\, the population of and interconversion among multiple states\, are of
 ten evoked to explain function.  The experimental characterization of prot
 ein dynamics to fully uncover their role however is challenged by both the
  spatial heterogeneity of proteins and the rapid interconversion of potent
 ially important conformational states.  Our group combines the inherent te
 mporal resolution of linear and two-dimensional infrared spectroscopy with
  the spatial resolution afforded by site-selective incorporation of vibrat
 ional reporter groups\, which provide frequency-resolved absorptions to ch
 aracterize rapidly occurring changes in local environments in proteins.  I
  will share several vignettes about our application of this approach towar
 d understanding the molecular recognition of protein systems:  Src homolog
 y 3 domain recognition of proline-rich motifs\, cytochrome P450cam regiose
 lectivity\, and plastocyanin recognition by cytochrome f.  Our studies res
 olve rapid dynamics at specific locations in the proteins and implicate th
 eir involvement in function.\n\nposter
GEO:42.449741;-76.481209
LOCATION:Clark Hall\, 700
SUMMARY:Biophysics Colloquium with Megan Thielges
URL;VALUE=URI:https://events.cornell.edu/event/biophysics_colloquium_with_m
 egan_thielges
CATEGORIES:Seminar
END:VEVENT
END:VCALENDAR