Cornell University

Hosted by: Michelle Wang

Title: How Basal Transcription Initiation Kinetics Determine Regulatory Outcomes

Abstract: Classical transcription factors regulate the rate of bacterial transcription by recognizing sequence-dependent motifs in their target promoters. They then either interact productively with RNAP to enact activation or block access of the polymerase in order to enact repression. However, a growing class of factors are recruited to the promoter via the polymerase directly. Curiously, without exhibiting a clear sequence dependence, these factors are capable of differential regulation. Specifically, they activate some promoters while repressing others while utilizing the same molecular contacts. In my seminar, I will review our work dissecting the kinetic mechanism of two essential mycobacterial transcription factors and will describe a model of differential regulation for this class of factors.

0 people are interested in this event


Join Zoom Meeting 
https://cornell.zoom.us/j/95479809684?pwd=Y0F1QUJOam83S3VUeURVaDN3RzdoQT09 ;
Meeting ID: 954 7980 9684 
Passcode: 510285 
One tap mobile 
+16465189805,,95479809684# US (New York) 
+16468769923,,95479809684# US (New York) 
Dial by your location 
        +1 646 518 9805 US (New York) 
        +1 646 876 9923 US (New York) 
        +1 301 715 8592 US (Washington DC) 
        +1 312 626 6799 US (Chicago) 
        +1 470 250 9358 US (Atlanta) 
        +1 470 381 2552 US (Atlanta) 
        +1 651 372 8299 US (Minnesota) 
        +1 786 635 1003 US (Miami) 
        +1 253 215 8782 US (Tacoma) 
        +1 346 248 7799 US (Houston) 
        +1 602 753 0140 US (Phoenix) 
        +1 669 219 2599 US (San Jose) 
        +1 669 900 6833 US (San Jose) 
        +1 720 928 9299 US (Denver) 
        +1 971 247 1195 US (Portland) 
Meeting ID: 954 7980 9684 
Find your local number: https://cornell.zoom.us/u/adcFtHQnp ;
Join by SIP 
95479809684@zoomcrc.com 
Join by H.323 
162.255.37.11 (US West) 
162.255.36.11 (US East) 
115.114.131.7 (India Mumbai) 
115.114.115.7 (India Hyderabad) 
213.19.144.110 (Amsterdam Netherlands) 
213.244.140.110 (Germany) 
103.122.166.55 (Australia Sydney) 
103.122.167.55 (Australia Melbourne) 
149.137.40.110 (Singapore) 
64.211.144.160 (Brazil) 
69.174.57.160 (Canada Toronto) 
65.39.152.160 (Canada Vancouver) 
207.226.132.110 (Japan Tokyo) 
149.137.24.110 (Japan Osaka) 
Meeting ID: 954 7980 9684 
Passcode: 510285 
Join by Skype for Business 
https://cornell.zoom.us/skype/95479809684 ;

User Activity

No recent activity