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Biophysics Colloquium - Arne Gericke - Worcester Polytechnic

Wednesday, September 30, 2020 at 4:00pm

Virtual Event

Hosted by Gerald W. Feigenson

Title: Physical chemical foundations of phosphoinositide clustering and signaling 

Abstract: Phosphoinositide lipids (PIPs) are only minor constituents of biological membranes but despite their low abundance they provide spatiotemporal control for an extraordinary array of cellular functions. The rich chemical functionality of the phosphoinositide headgroup is the foundation for interactions with distinct protein motifs that bind with high specificity to select phosphoinositide species. It is equally the basis for the clustering of phosphoinositides that leads to the formation of lipid/protein signaling platforms with distinct physiological functions. In this talk, I will discuss our data highlighting mutual phosphoinositide interactions via hydrogen bond formation and I will report on our recent findings about the structural origins of cholesterol induced phosphoinositide clustering.    

Poster

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Event Type

Colloquium

Tags

biophysics, biophysics_colloquium, lassp

Contact E-Mail

lmr268@cornell.edu

Contact Name

Lea Reagan

Contact Phone

6072423939

Speaker

Arne Gericke

Speaker Affiliation

Worcester Polytechnic

Dept. Web Site

https://www.wpi.edu/people/faculty/agericke

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