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Wednesday, September 30, 2020 at 4:00pm
Virtual EventHosted by Gerald W. Feigenson
Title: Physical chemical foundations of phosphoinositide clustering and signaling
Abstract: Phosphoinositide lipids (PIPs) are only minor constituents of biological membranes but despite their low abundance they provide spatiotemporal control for an extraordinary array of cellular functions. The rich chemical functionality of the phosphoinositide headgroup is the foundation for interactions with distinct protein motifs that bind with high specificity to select phosphoinositide species. It is equally the basis for the clustering of phosphoinositides that leads to the formation of lipid/protein signaling platforms with distinct physiological functions. In this talk, I will discuss our data highlighting mutual phosphoinositide interactions via hydrogen bond formation and I will report on our recent findings about the structural origins of cholesterol induced phosphoinositide clustering.
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Lea Reagan
6072423939
Arne Gericke
Worcester Polytechnic
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