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MAE Colloquium -Kyle Allen, Ph.D., Associate Professor, Biomedical Engineering, University of Florida

Tuesday, September 18, 2018 at 4:00pm

Thurston Hall, 203
Central Campus

ABSTRACT:  Osteoarthritis (OA) is a non-life-threatening, but incurable, disease that ultimately results in chronic pain and disability. However, OA pain and disability is a complex phenomenon, as the severity of joint degeneration in OA patients does not necessarily correlate to the severity of symptoms.  Moreover, animal models of acute joint pain may not fully replicate chronic pain mechanisms in OA. Unfortunately, the current reality for OA drug development is that safety and efficacy will need to be tested in a preclinical model prior to clinical testing. Thus, the lack of unifying relationships between OA pathogenesis and symptoms remains a significant obstacle to the development and translation of OA therapies. To improve the translation and development of OA therapeutics, our ability to investigate preclinical OA models must become more relevant to OA treatment in the clinic.  This challenge is the central motivator for my research program, where my laboratory is developing engineering technologies to improve the preclinical-to-clinical translation of emerging OA diagnostics and therapeutics, including behavioral assays of symptomology in rodent preclinical models and magnetic nanoparticle technologies to assess joint-level molecular changes.  These technologies can impact the preclinical evaluation of OA interventions, the development of novel diagnostics and disease modifying drugs, and the creation of new biological therapies for OA.

BIOGRAPHICAL SKETCH:  Dr. Kyle D. Allen is an Associate Professor of Biomedical Engineering at the J. Crayton Pruitt Family Department of Biomedical Engineering at the University of Florida.  He also serves as the Associate Chair of Undergraduate Studies and has been recognized with a UF TERM Professorship and the J. Crayton Pruitt Assistant Faculty Fellowship.  His research has been continuously supported by the National Institutes of Health since 2006, including support from the National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Aging, and the Office for Research on Women’s Health.  In the Fall of 2009, Dr. Allen received a K99/R00 Pathways to Independence Award from NIAMS, and in the Fall of 2011, he started a new laboratory at the University of Florida in the J. Crayton Pruitt Family Department of Biomedical Engineering.  He is an active member of the Biomedical Engineering Society (serving as incoming chair of the National Student Affair Committee), the Osteoarthritis Research Society International, and the Orthopedic Research Society (serving on the New Investigator Mentoring Committee and as Treasurer of the Meniscus Section).  He is also a standing member of the Skeletal Biology Structure and Regeneration Study Section and an Associate Editor for the ASME Journal of Biomechanical Engineering.
 

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