LASSP and A&EP SEMINAR

Tuesday, November 28, 2017 at 12:20pm to 1:45pm

Clark Hall, 700
Central Campus

Thomas Gregor, Laboratory for the Physics of Life, Princeton University, Princeton, NJ, will present seminar. Professor Itai Cohen, host. 

Seminar Title: How the physics of enhancers shapes development

Abstract: Enhancers are small regulatory pieces of DNA that control the activity of genes, which eventually determine cellular fates during the development of multicellular organisms. They need to measure the concentrations of various input effector molecules, called transcription factors, and then act over often very long distances along the DNA in order to activate a distantly located gene. In this talk I will present my laboratory’s progress on two fundamental physical properties of these enhancers: 1. How do enhancers decode the information of the input transcription factors and then transduce it into a precise output? 2. How do enhancers operate at long distances to instruct gene activity? We use a combination of genome editing, live imaging and statistical mechanics techniques to address these questions in the fruit fly embryo.

Poster available.

Event Type

Seminar

Departments

LASSP, Applied and Engineering Physics, Physics

Tags

lassp_and_aep_seminar

Website

http://www.lassp.cornell.edu/events/

Contact E-Mail

dem8@cornell.edu

Contact Name

Douglas E. Milton, Sr.

Contact Phone

(607)255-9684

Speaker

Thomas Gregor

Speaker Affiliation

Princeton University

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