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Tuesday, October 1, 2019 at 4:00pm
700 Clark Hall
Hosted by Itai Cohen
Artificial Life, Self-replication, Exponential growth, Directed evolution and Freeform Colloidal Architecture with DNA Origami
Self-replication and evolution under selective pressure are inherent phenomena in life, but few artificial systems exhibit these phenomena. We have designed a process and a system of DNA origami tiles that exponentially replicate a seed pattern, doubling (or more) the copies in each diurnal-like cycle of temperature and UV illumination, producing more than 7 million copies in 24 cycles. We demonstrate environmental selection in growing populations by incorporating pH sensitive binding in two sub-populations. We also use DNA origami to self-assemble complex arrangements of colloids and emulsion droplets with highly specific geometry showing control over valence, position, dihedral angles and chirality.