Dr. Ronald Zuckermann
Facility Director, Biological Nanostructures
Lawrence Berkeley National Laboratory
"Construction of well-defined nanostructures from flexible peptoid polymers"
Abstract: A fundamental challenge in materials science is to create synthetic nanoarchitectures that rival the structural complexity found in nature. A promising bioinspired approach is to synthesize sequence-defined polymer chains that fold and assemble into precise protein-like structures. In order to efficiently produce such information-rich polymer sequences, we use the automated solid-phase submonomer synthesis method to generate sequence-defined peptoid polymers up to 50 monomers in length. The method uses readily available primary amine synthons, allowing hundreds of chemically diverse sidechains to be cheaply introduced. We use this method, along with with computational modeling, to design, synthesize, assemble and engineer a variety of protein-mimetic nanostructures. Here we examine how flexible peptoid sequences can be tiled together to form highly ordered supramolecular assemblies of nanosheets and nanotubes, and compare these molecular structures to the fundamentals of protein structure.
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