Chemical Engineering Seminar: G.V. Rex Reklaitis (Purdue University)

Monday, February 27, 2017 at 9:00am

Olin Hall, 165

Dr. G.V. Rex Reklaitis
Burton and Kathryn Gedge Distinguished Professor of Chemical Engineering
Purdue University

"Process System Engineering Contributions to Pharmaceutical Development, Manufacturing and Patient Treatment"

Abstract: The growing global healthcare needs of the aging populations of the developed economies and the burgeoning but underserved needs of developing economies are stimulating engineering research and development seeking innovative solutions tailored to these diverse market features.  The pharmaceutical sector of the healthcare industry in particular has emerged as a fertile domain in which engineers can contribute using their strengths in quantitative and model-based approaches. In this seminar we will briefly recap the context within which the pharmaceutical industry is operating, the basic features of the life cycle of pharmaceutical products, the role of regulation in that life cycle, and the characteristics of the manufacturing process as practiced in this industry. We will outline some opportunity areas for the application of process systems engineering methodology to the effective management of aspects of the product development process, in improvements to current manufacturing systems and to innovations in manufacturing modes and  product administration  practices. We will review some of the model-based approaches, which have been proposed to support the management of the product development pipeline. We will show that the conversion of traditional batch process to automated continuous processes is proving to be an especially productive area for the application of on-line sensing, process modeling and plant-wide control methodologies. This transition is also stimulating the investigation of integrated plant wide-operations and supply chain management strategies. Among the exciting innovations in manufacturing modes is the concept of point of use manufacture, which is employs small scale, distributed manufacturing system designs. These new manufacturing modes combined with patient specific predictive models of drug pharmacokinetics /dynamics have enormous potential to improve patient outcomes through individualized treatment.

Bio: G.V. Rex Reklaitis is Burton and Kathryn Gedge Distinguished Professor of Chemical Engineering at Purdue University, where he has served as the Director, Computer Integrated Process Operations Center; Deputy Director, NSF ERC on Structured Organic Particulate Systems; and Head, School of Chemical Engineering. His expertise lies in process systems engineering, the application of information and computing technologies to process and product design, process operations and supply chain management. Current application interests lie in energy systems and healthcare engineering. These applications include study of shale gas supply chains and multi-sourced electric power systems as well as and developments in pharmaceutical product and process design, manufacture and drug product administration. He was educated at the Illinois Institute of Technology (BS ChE) and received MS and PhD degrees from Stanford University. He is a member of the US NAE, fellow of AIChE, past Editor-in-Chief of Computers & Chemical Engineering and currently is member of three editorial advisory boards. Among his recognitions, he has received the Computing in Chemical Engineering Award (AICHE), the ChE Lectureship Award  (ASEE), the George Lappin and Van Antwerpen Awards (AIChE) , the Long Term Achievements in Computer Aided Process Engineering Award of the European Federation of Chemical Engineering and the Pruitt Award of the Council for Chemical Research. He has served on the Board of Directors of AICHE, the Council for Chemical Research and the CACHE Corporation. He has published over 260 papers and book chapters and edited/authored nine books.

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Chemical and Biomolecular Engineering

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Stephanie Palcich

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Gintaras V. Rex Reklaitis

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Purdue University

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