Cornell University

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CBE Seminar: Chaitan Khosla: Assembly Line Biosynthesis of Polyketide Antibiotics

Monday, September 14, 2015 at 9:00am to 10:00am

Olin Hall, 165

Chaitan Khosla

Wells H. Rauser and Harold M. Petiprin Professor in the School of Engineering; Professor of Chemical Engineering, Chemistry, and Biochemistry
Stanford University 

Assembly Line Biosynthesis of Polyketide Antibiotics

Abstract: Many complex natural products are synthesized by multi-enzyme systems that operate as assembly lines. Their apparently modular architecture has opened the door to biosynthetic engineering of new natural products by rationally manipulating the DNA encoding these megasynthases. Understanding the structures and mechanisms of these assembly lines represents a challenging and exciting frontier in multifunctional catalysis. 

https://chemistry.stanford.edu/faculty/chaitan-khosla

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