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Monday, September 14, 2015 at 9:00am to 10:00am
Chaitan Khosla
Wells H. Rauser and Harold M. Petiprin Professor in the School of Engineering; Professor of Chemical Engineering, Chemistry, and Biochemistry
Stanford University
Assembly Line Biosynthesis of Polyketide Antibiotics
Abstract: Many complex natural products are synthesized by multi-enzyme systems that operate as assembly lines. Their apparently modular architecture has opened the door to biosynthetic engineering of new natural products by rationally manipulating the DNA encoding these megasynthases. Understanding the structures and mechanisms of these assembly lines represents a challenging and exciting frontier in multifunctional catalysis.
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