Cornell University

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CAM Colloquium: Jacob Scott, M.D. (Cleveland Clinic) - Understanding the evolution of resistance: a comprehensive and integrated mathematical and experimental research program

Friday, April 28, 2017 at 3:30pm

Frank H. T. Rhodes Hall, 655

The evolution of resistance remains an elusive problem in the treatment of both cancer and infectious disease, and represents one of the most important medical problems of our time. While the illnesses are different on several non-trivial levels including timescale and complexity, the underlying biological phenomenon is the same: Darwinian evolution. To comprehensively approach these problems, I have focused my attention on building a broad suite of investigations centered around the causes and consequences of the evolutionary process in these contexts. I will discuss my and my collaborator's efforts to; model the evolutionary process on the genomic scale in both an analytic (Markov process) and stochastic (individual based model and inference) format; to quantify in vitro competition and interaction between cancer cell lines through an evolutionary game theoretic lens using time-lapse microscopy and computer vision; and to understand the evolutionary contingencies inherent in collateral sensitivity in E. coli and ALK mutated non-small cell lung cancer.

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Event Type

Seminar

Departments

College of Engineering, Mathematics, Center for Applied Mathematics

Tags

engineering, math, center for applied math, cam, College of Engineering, mathematics, center for applied mathematics

Website

http://www.cam.cornell.edu

Speaker

Jacob Scott, M.D.

Speaker Affiliation

Department of Translational Hematology and Oncology Research, Cleveland Clinic

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