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Thursday, March 8, 2018 at 9:00am to 10:00am
This week we welcome Dr. Kristen Naegle from Washington University in St. Louis.
"Unsupervised Learning to Unravel Differential Cell Fate Outcomes"
Abstract: Cells are constantly receiving cues from the outside world and responding to them by altering their physiological fate by transducing this signal via intracellular biochemical networks. An important mechanism that many cell networks utilize to transduce these signals is the regulation of protein tyrosine phosphorylation. The addition of a phosphate group to a tyrosine residue can cause changes in protein activity, localization, and interactions. Given the sheer size and complexity of these biochemical networks, computational methods are needed to help unravel how network flow is established and altered by changes in cell context, such as different tissue types or alterations as we seen in diseases like cancer. In this talk, I will introduce computational methods we have developed that have pointed to specific network alterations in HER2-ovexpressing cells that result in increased migration and the cell-based experiments we have used to test computationally-derived hypotheses. Our findings suggest there is power in considering protein-protein interactions as diagnostic tools for cancer and that, by combining systems-level experiments with computation, we can discover novel protein-protein interactions.
Bio: Kristen Naegle’s research interests include computational molecular systems biology, post-translational modifications, signal transduction and proteomics. She combines computational mining and modeling techniques with experimental molecular biology approaches to understand the function of post-translational modifications in regulatory networks of the cell. The specific focus of her work is on those regulatory events that are involved in the complex development and propagation of human disease with the possibility of discovering new therapeutic interventions in diseases like cancer, diabetes and neurodegenerative disorders.
Dr. Naegle joined Washington University in St. Louis in 2012. She was previously a postdoctoral associate at the Koch Institute for Integrative Cancer Research and Department of Biological Engineering at the Massachusetts Institute of Technology.