Friday, September 8, 2017 at 2:30pm to 3:30pm
We welcome our next speaker, Dr. Edward Botchwey, Associate Professor of the Coulter Department of Biomedical Engineering at Georgia Tech College of Engineering and Emory School of Medicine.
"Biomaterials for local education of immune cells and soft tissue
ABSTRACT: Innate immune cells play a critical role in tissue development, homeostasis, and injury repair. These cells guide vascular remodeling, stimulate local stem and progenitor cells, and direct structural repair of tissues such as muscle and skin. Therefore, there is great interest in harnessing this powerful endogenous cell source through immunoregenerative biomaterial engineering design. These materials seek to harness specific subpopulations of monocytes/macrophages to promote repair by influencing their recruitment, positioning, differentiation, and function within a damaged tissue. Monocyte and macrophage phenotypes span a continuum of inflammatory (M1) to anti-inflammatory or pro-regenerative cells (M2) and their heterogeneous functions are highly dependent on microenvironmental cues within the injury niche. Increasing evidence suggests that division of labor among subpopulations of monocytes and macrophages could allow for harnessing regenerative functions over inflammatory functions of myeloid cells; however, the complex balance between necessary functions of inflammatory versus regenerative myeloid cells is not well understood. A number of opportunities exist to exploit known signaling systems of specific populations of monocytes/macrophages to promote repair and to better understand the biological and pathological roles of myeloid cells. This talk will outline the characteristics of distinct populations of monocytes and macrophages, identify the role of these cells within diverse tissue injury niches, and explore smart biomaterial design strategies that harness the intrinsic inflammatory response to enhance healing.
RESEARCH INTERESTS: Botchwey's interests are in tissue engineering and biomaterials, microvascular growth and remodeling and stem cell engineering.
The Botchwey Lab takes a multidisciplinary approach for improvement of tissue engineering therapies through the study of microvascular remodeling, inflammation resolution and host stem cells. Their goal is development of effective new strategies to repair, replace, preserve or enhance tissue or organ function.