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Friday, October 4, 2019 at 2:30pm to 3:30pm
For our next guest speaker, we welcome Dr. Christine Hendon from Columbia University. She is an Associate Professor in the Department of Electrical Engineering.
Characterizing Tissue Fiber Architecture and Composition with Optical Coherence Tomography
Abstract: The research goals of the Structure-Function Imaging Laboratory are to develop platform optical imaging systems to enable structure-function analysis of biological organ systems. Towards this goal, we develop optical coherence tomography (OCT) and near infrared spectroscopy (NIRS) systems and automated processing tools to correlate tissue microstructure to electrical conduction and mechanical contraction. Within this talk, I will highlight our effort towards characterizing tissue architecture and composition with OCT. Quantifying collagen fiber architecture has clinical and scientific relevance across a variety of tissue types and adds functionality to otherwise largely qualitative imaging modalities. OCT is uniquely suited for this task due to its ability to capture the collagen and muscle microstructure over larger field of view with micron scale resolution. I will highlight our image processing algorithms for composing mosaics of OCT images for centimeter scale area imaging, machine learning algorithms for tissue composition, and fiber orientation and dispersion algorithms for characterizing tissue samples ranging from the human breast, heart, cervix, and uterus.
Bio: Christine received the B.S. degree from Massachusetts Institute of Technology in Electrical Engineering and Computer Science in 2004, along with the M.S. and Ph.D. degrees from Case Western Reserve University in Biomedical Engineering in 2007 and 2010, respectively. She completed her postdoctoral fellowship at the Wellman Center for Photomedicine at Massachusetts General Hospital and Harvard Medical School in 2012. She joined Columbia University in 2012. She teaches courses on image processing and optical systems and leads the Structure Function Imaging Laboratory. Her work is currently funded by the National Science Foundation and the National Institute of Health, and she has received recognition for her work from Forbes' 30 under 30 in Science and Healthcare (2012), MIT Technology Review's 35 under 35 Innovators (2013), NIH New Innovator Award (2014), NSF CAREER Award (2015), and recently by President Obama, receiving a 2017 Presidential Early Career Award in Science and Engineering.