Thursday, February 20, 2014 at 4:15pm to 5:15pm
BME 7900: Alyssa Panitch - Purdue - "Lessons from biology – approaches to inhibit inflammation and scarring"
Using biological molecules as templates for designing engineered analogues, we have developed a class pro-teoglycan mimetic molecular therapeutics. The first group of molecules is collagen-binding peptidoglycans that demonstrate many of the key functions of native small leucine-rich proteoglycans such as decorin. These proteoglycans are key ingredients for proper function and organization of collagenous tissues - the most abundant of the body. The proteoglycan mimetic de-sign simplifies the native molecules to a polysaccharide chain with covalently attached collagen-binding pep-tides, but has the advantage of design control and the ability of synthetic scale-up. We have tailored these mi-metics for applications in dermal healing and inhibition of intimal hyperplasia following balloon angioplasty.
The second group of molecules seek to function like the more complex proteoglycan, aggrecan. Aggrecan plays many roles in cartilage and is critical in maintaining the compressive strength of articular cartilage and in pro-tecting other extracellular matrix molecules from prote-olytic degradation during inflammatory episodes. The Aggrecan mimetic recapitulates these functions after diffusion into either damaged or healthy cartilage.