Cornell University

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Biophysics Colloquium with Luke Chao

Wednesday, September 25, 2019 at 4:00pm to 5:00pm

Clark Hall, 700
Central Campus

Luke Chao, Department of Molecular Biology, Harvard University

Host: Holger Sondermann

Molecular mechanisms for inner-mitochondrial membrane fusion by Opa1

Mitochondrial membrane dynamics and ultrastructure are intimately tied to the organelle function. Opa1, the mitochondrial inner membrane fusogen, plays central roles in organelle rearrangement and cristae morphology. Opa1 couples nucleotide hydrolysis to conformational rearrangement and self-assembly to catalyze its membrane activities. We present a view of Opa1 structure and function from single-particle cryo-EM and in vitro reconstitution. We discuss the relationship between different conformational state and membrane activity and how processing of Opa1 by mitochondrial inner-membrane proteases may regulate activity.

Poster

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Event Type

Seminar

Departments

LASSP

Tags

biophysics, lassp, biophysics_colloquium

Website

http://biophysics.cornell.edu/index.html

Hashtag

#biophysics

Contact E-Mail

jdf55@cornell.edu

Contact Name

Jonathan

Contact Phone

255-8101

Speaker

Luke Chao

Speaker Affiliation

Harvard University

Open To

public

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