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Wednesday, September 25, 2019 at 4:00pm to 5:00pm
Clark Hall, 700
Luke Chao, Department of Molecular Biology, Harvard University
Host: Holger Sondermann
Molecular mechanisms for inner-mitochondrial membrane fusion by Opa1
Mitochondrial membrane dynamics and ultrastructure are intimately tied to the organelle function. Opa1, the mitochondrial inner membrane fusogen, plays central roles in organelle rearrangement and cristae morphology. Opa1 couples nucleotide hydrolysis to conformational rearrangement and self-assembly to catalyze its membrane activities. We present a view of Opa1 structure and function from single-particle cryo-EM and in vitro reconstitution. We discuss the relationship between different conformational state and membrane activity and how processing of Opa1 by mitochondrial inner-membrane proteases may regulate activity.