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Wednesday, February 13, 2019 at 4:00pm to 5:00pm
Clark Hall, 700
Cancelled Due to Weather
Joel Meyerson, Weill Cornell Medical College
Host: Chris Fromme
Investigating the structural basis of glutamate receptor gating using cryo-EM
Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate excitatory synaptic transmission in the vertebrate brain. In performing this role, iGluRs adopt three major functional states: a resting state with closed ion channel, an active state with bound glutamate and open ion channel, and a desensitized state where glutamate is still bound in the receptor but the channel is closed. A fundamental question in iGluR structural biology is how the receptor structurally traverses these three states. The seminar will focus on this question in the context of a collection of AMPA and kainate subtype iGluR structures determined by cryo-EM. The results have revealed a complex interplay of domain motions, domain interactions, and symmetry mismatches within the receptor, that are at the heart of iGluR function