Cornell University

Biophysics Colloquium with Jeff Gelles

Wednesday, April 12, 2017 at 4:00pm to 5:00pm

Clark Hall, 700
Central Campus

Jeff Gelles, Brandeis University

Host: Peng Chen

A hitchhiker’s guide: How proteins collaborate to regulate transcription

Purified RNA polymerases in isolation can transcribe DNA.  In cells, however, messenger RNAs are not made by RNA polymerases alone.  Instead, the formation and function of transcription complexes in all organisms are modulated by general transcription factors that that interact with RNA polymerase, DNA, and the nascent transcript.  I will describe multi-wavelength single-molecule fluorescence experiments that reveal the mechanisms by which multiple proteins collaborate to control transcription in bacteria.  These studies demonstrate kinetically-controlled programming of the activities of transcription initiation and elongation complexes by dynamic association and release of transcription factors and reveal an alternative transcription cycle for bacterial RNA polymerase. 


Event Type





biophysics, biophysics_colloquium, lassp

Contact E-Mail

Contact Name

Jonathan Fuller

Contact Phone



Jeff Gelles

Speaker Affiliation

Brandeis University

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