Cornell University

Biophysics Colloquium with Hong Li

Wednesday, October 4, 2017 at 4:00pm to 5:00pm

Clark Hall, 700
Central Campus

Hong Li, Florida State University

Host: Ailong Ke

Learning the Rules of Substrate Specificity in RNA-guided Enzymes 

Small non-coding RNA can act as effective guides for protein enzymes in mounting chemical changes on large nucleic acid substrates, such as ribosomal RNA and viral genomes. The programmability of the RNA-guided enzymes makes them attractive targets for developing nucleic acid detection and genome science tools. Unlike protein-only enzymes, the RNA-guided enzymes bind substrates through Watson-Crick base pairing and thus have unique set of rules to impart specificity. Three examples RNA-guided enzymes, an RNA 2'-OH methyltranferase, a pseudouridylase, and a DNA endonuclease, will be discussed to explore substrate specificity of these unique enzymes. We learned that RNA structure, solvent accessible area of the target, and DNA topology can influence substrate specificity.


Event Type





biophysics_colloquium, lassp

Contact E-Mail

Contact Name

Jonathan Fuller

Contact Phone



Hong Li

Speaker Affiliation

Florida State University

Google Calendar iCal Outlook

Recent Activity