Adam Hall, Virginia Tech - Wake Forest
Host: Iwijn De Vlaminck
Novel detection strategies for disease biomarkers using nanotechnology
Nanoscale devices have long held potential for disease diagnostics due to their inherent scale and sensitivity, but challenges in implementation, reproducibility, and cost have hampered progress. In our lab, we are working to address these challenges by improving both the production of and the applications for the emerging platform of solid-state nanopores. I will first discuss our advanced fabrication tools for making nanopore devices with precision, speed, and flexibility, and then I will present two novel assays we have developed using the resulting system. With the first, we are able to detect nucleic acid biomarkers that include epigenetic modifications and specific sequences with relevance to fields that include oncology and infectious diseases. With the second, we are able to assess native hydrophobic proteins that play a role in pathologies like Celiac’s disease.
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